In vitro photoprotective, antioxidant and antibacterial activity of Vernonia squarrosa (D. Don) Less

Vernonia squarrosa (D. Don) Less. (Asteraceae) is an ethnomedicinally important plant of unexplored medicinal potential. The Hydro-Methanolic Leaf Extract (HMLE) reveals presence alkaloids, terpenoid, tannins, phenols, flavonoids, saponins and also cardiac glycosides with notable amount phenol, flavonoid, ? carotene lycopene. high antioxidant activity HMLE when assessed by 2, 2 diphenyl 1-picrylhydrazyl (DPPH) shows significant EC50 value 11.63 ± 2.60 µg/ml. Photo-protection efficiency was determined expressed as Sun Protection Factor (SPF). Reasonably SPF 38 (SPF=38 at 200 µg/ml) provides UV blockage up to 98%. extract screened for antibacterial against four human pathogenic bacterial strains, Staphylococcus aureus (MTCC 2940), Pseudomonas aeruginosa 2453), Bacillus subtilis 441), Escherichia coli 739). Results showed prominent impact on these tested bacteria. Lupeol, a pentacyclic triterpenoid found be present dominant member in Gas chromatography–mass spectrometry (GC-MS) analysis HMLE. Lupeol compound diverse pharmaceutical applications. This the maiden report bioactive compounds from V. highlighting their antibacterial, photoprotective activities.